| CYP isoenzymes | |||||
| CYP17 1 subfamily, 1 gene
(steroid biosynthesis) | |||||
| Isoenzyme | Substrates | Inducer | Inhibitor | Alleles | Effects (alleles, interactions) |
| CYP17 | a portmanteau of two enzymes: 17 alpha hydroxylase and 17-20 lyase!; also metabolises aminopyrine | ketoconazole | A1 v A2 alleles implicated in a variety of hormone sensitive
tumours {?}; A2/A2 genotype less likely to be on Hormone Replacement
therapy!
blockade could turn off androgen synthesis! | ||
| Last update 2000-1-22 | Author jo@anaesthetist.com |