| X, Y, Z
|
| Drug |
CYP interaction |
Clinical consequences |
| yohimbine
| ? 2D6 : metabolism
| ?
|
| zafirlukast
| 2C9 : INHIBITS
(and metabolism)
| ? interaction with eg. warfarin
|
| 3A4 : inhibits
| 3A4 interactions (?)
|
| zanamivir
| minimal CYP interaction
| nil (?)
|
| zidovudine
| ?
| (interaction of this or other nucleoside analogues, and
other anti-retrovirals such as protease inhibitors is
NOT likely) [Clin Pharmacokinet 1999 Apr;36(4):289-304]
|
| zileuton
| 1A2 : metabolism
(also 2C9, 3A4 [Hayes] )
| interaction with theophyllin, {? also propranolol, warfarin}
|
| zolmitriptan
| CYP1A2 : metabolism [Xenobiotica 1999 Aug;29(8):847-57]
| ?
|
| zonisamide
| 3A4,5 : metabolism (also 2C19)
| potential for interaction with 3A4/5 inhibitors
[Eur J Clin Pharmacol 1998 Apr;54(2):177-83]
eg. ketoconazole, cyclosporin A and miconazole
|
| zotepine
| 3A4 {also 1A2, 2D6} : metabolism
| ?
|
| zuclopenthixol
| CYP2D6 : metabolism
| ?
|