|
CYP isoenzymes
++ = mitochondrial # = found in lung tissue | ||||||
| CYP1 2 subfamilies, 3 genes
(drug metabolism) | ||||||
| Isoenzyme | Substrates | Inducer | Inhibitor | Alleles | Effects (alleles, interactions) | |
| CYP1A1 # | Chlorinated benzenes, coumarin activation! | polycyclic hydrocarbons | propofol, N2O | *1 .. *4 | (Unclear) placental 1A1 is induced by maternal tobacco smoking
Note that 1A1 is primarily extrahepatic (lung, placenta). | |
| CYP1A2 # (about 13% of liver CYP) | caffeine, TCA, erythromycin, haloperidol, theophylline, paracetamol, ropivacaine, propranolol, naproxen, tacrine, verapamil, ? propafenone metabolites, R-warfarin, coumarin activation (may also activate procarcinogens!) ! | phenytoin, phenobarbitone, omeprazole, lansoprazole (but no significant interaction with theophyllin) , polycyclic hydrocarbons (smoking, charcoal-broiled meat!), rifampicin | cimetidine >> ranitidine, fluvoxamine, grapefruit juice!
| *1A .. *1F, *2 | *1C : decreased activity *1F : more inducible (thought to predispose to cancer) several month delay in expression post-partum | |
| CYP1B1 | ? | ? | ? | *1 .. *4, *11 .. *26 | (unclear: may predispose to lung/breast carcinoma); congenital glaucoma! | |
| Last update 2000-1-22 | Author jo@anaesthetist.com |