| CYP isoenzymes | |||||
| CYP4 5 subfamilies, 9 genes, 2 pseudogenes
(fatty acid, or arachidonic acid, metabolism) 4A9 an artefact. | |||||
| CYP4A11 | The main human fatty acid omega hydroxylase. | ||||
| CYP4B1 | (may mediate corneal angiogenesis and inflammation by forming 12(R) HETE etc. in response to corneal hypoxia) | (present in placenta) | |||
| CYP4F2 | The principal catalyst of 20-HETE formation; (? omega hydroxylates and thus inactivates leukotriene B4 : the main disposal mechanism for LTB4 : see also 4F3); | ||||
| CYP4F3 | 4F3A breaks down LTB4 in leukocytes; 4F3B is found in liver but not leukocytes: the two are formed by alternative splicing. | ||||
| CYP4F8 | Forms 19R-hydroxyprostaglandins in seminal vesicles | ||||
| CYP4F11 | ? | ||||
| CYP4F12 | ? | ||||
| CYP4X1 | ? | ||||
| CYP4Z1 | ? | ||||
| Last update 2000-1-22 | Author jo@anaesthetist.com |