Sepsis

Sepsis is a big issue in ICU. Some years ago we became uncomfortable with the PROWESS study (particularly the 'hung jury' when it came up for FDA approval). We explore the issues in the first paper below. The second paper (with the accompanying editorial comment) is a relic from the earliest days of anaesthetist.com.

• Controversies surrounding activated Protein C (Xigris).

• Some years ago we published a paper from the CIS on Extracorporeal "detoxification" and sepsis mortality . Please also see the associated editorial comment.