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Cytochrome P450 : Alphabetical drug list B |
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| B | ||
| Drug | CYP interaction | Clinical consequences |
| Barbiturates | 3A4 (3A5,3A7) : INDUCE | Many potential 3A4-based interactions |
| barnidepine (calcium channel blocker) | 3A4 : metabolism | potential interaction with cyclosporine |
| 2B6 : inhibits | ? | |
| 2c9 : inhibits | ? | |
| 2D6 : inhibits | ? | |
| 2C19 : inhibits | ? | |
| 3A4 : inhibits | ? | |
| Benzodiazepines {temazepam is exception to 3A4 metabolism} | CYP3A4 : hi activity | less effective |
| CYP3A4 : low activity | delayed clearance | |
| bepridil (Calcium 'antagonist' with anti-arrhythmic properties) | 1A2 : mild inhibition
(? metabolism 3A4) | ?? significant |
| Beta-blockers | CYP2D6 : low activity | prolonged and hi effect |
| bezafibrate (see fibrates) | 3A4 : metabolism | potential for 3A4 interactions |
| bisoprolol | 2D6 (stereoselective, R>S) AND 3A4 (not) | ? |
| bromocriptine | 3A4 ? metabolism | ? |
| brotizolam | 3A4 [Xenobiotica 1997 Sep;27(9):913-22] | ? |
| (bufuralol) | 2D6 : metabolism (used as a reference for 2D6 metabolism, but 2C19 may catalyse the same reaction! [Drug Metab Dispos 1999 Sep;27(9):1024-8] ) | ? |
| buspirone | 3A4 : substrate | grapefruit juice raises levels a lot! [Clin Pharmacol Ther 1998 Dec;64(6):655-60] similarly with erythromycin, itraconazole [Clin Pharmacol Ther 1997 Sep;62(3):348-54] |
| busulfan | 3A4 : METABOLISM | interaction with eg intraconazole |
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| Page author: jo@anaesthetist.com | Last update: 2000-6-22 |