| CYP isoenzymes | |||||
| CYP7 7 alpha hydroxylase (A=liver, B=brain)
(bile acid biosynthesis; brain metabolism) | |||||
| Isoenzyme | Substrates | Inducer | Inhibitor | Alleles | Effects (alleles, interactions) |
| CYP7A1 (liver specific) = cholesterol 7 alpha hydroxylase | (first and rate-limiting step of bile acid synthesis ie. cholesterol degradation) See also CYP51 | taurine; cholesterol; colestipol; | bile acids | ? |
low activity may increase plasma LDL !
Congenital absence (rare) causes neonatal cirrhosis+cholestasis |
| CYP7B1 brain ( also testis, ovary, prostate, liver, colon, kidney, small bowel ) = oxysterol 7 alpha hydroxylase | (synthesis of neurosteroids: 7 alpha hydroxy DHEA, & alpha hydroxy pregnenolone) | ||||
| Last update 2000-1-22 | Author jo@anaesthetist.com |