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Cytochrome P450 : Alphabetical drug list U V |
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| U,V | ||
| Drug | CYP interaction | Clinical consequences |
| valproic acid (valproate) {felbamate lowers valproate clearance by inhibiting beta oxidation!} | 2C19 : metabolism | ? |
| ? 2C9 : metabolism (and/or 2A6) [J Pharmacol Exp Ther 1997 Nov;283(2):698-703] | ||
| valsartan (AT II blocker) | 2C9 : metabolism | ? |
| valspodar | 3A4 metabolism (also inhibits, IC50 1-6 µM) [Drug Metab Dispos 1998 Aug;26(8):802-11] | interaction potential |
| venlafaxine | 2D6 : metabolism | Minimal interactions if any. |
| verapamil (See also Calcium channel blockers) | CYP1A2 : low activity | ? |
| CYP2C8 : metabolised | ? | |
| CYP2C9 : metabolism (& minor inhibition; also inhibits 2D6 a little) | ? | |
| CYP3A4 : metabolism | ? | |
| 3A4: INHIBITS (IC50 2 µM ?) | ? | |
| vesnarinone {oral inotrope} | 3A4 : metabolism | ? |
| 2E1 : metabolism - minor | 'nil' | |
| vigabatrin | NO interaction with 3A4 | (? nil) |
| vinblastine | 3A4 : substrate | See vincristine |
| 3A4 : inhibits (IC50 = 5 µM) | ? | |
| vinca alkaloids | 3A4 : metabolism | See vincristine (metabolism in general is similar) |
| vincristine | 3A4 : substrate | potential for marked toxicity from 3A4 inhibitors: eg. azole antifungals (itraconazole, ketoconazole), cyclosporine, isoniazid, and nifedipine [Pharmacotherapy 1998 Nov-Dec;18(6):1304-7] |
| vindesine | 3A4 : metabolism | potential interactions |
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| Page author: jo@anaesthetist.com | Last update: 2000-6-22 |