Cytochrome P450 : Alphabetical drug list
Quick Links:
1A2 2C9 2C19 2D6 2E1 3A4
Have you read our disclaimer?
Drug CYP interaction Clinical consequences
ibuprofen 2C9 : substrate ?
2C8 ?
ifosfamide {ifosphamide} (prodrug activated by 2B1 ) CYP2B6 : metabolism (S-) enantiomer ?
3A4 metabolises (R) enantiomer ?
imipramine (See Tricyclics   ? 1A2, 2C19; 3A4  
2D6 : metabolism potential for interaction
2D6 : ? inhibits ?
indinavir (HIV PI) 3A4 : metabolism ?
3A4 : INHIBITS interaction potential
2D6 : inhibits (Ki 15.6) ?
indoramine 2D6 : substrate ?
insulin 1A2 : INDUCES ! ?
indomethacin 2C19 : substrate ?
irbesartan (AT II blocker) 2C19 : metabolism ?
irinotecan (anti-tumour) 3A4 : metabolism ? interaction with ketoconazole, troleandromycin
isoflurane CYP2E1 : METABOLISM ? may inhibit eg EDHF production
isoniazid (INH) CYP2E1 : INDUCES
(and ? metabolism)
worsens paracetamol hepatotoxicity
2C9 : INHIBITS phenytoin and warfarin toxicity [Am J Med Sci 1999 May;317(5):304-11]
isotretinoin 3A4 : inhibits (other retinoids similar: etretinate, acitretin) interaction with e.g. cyclosporin
isradipine (see also calcium channel blockers) 3A4 : metabolism ?
2D6 : inhibits decreases propranolol removal [Fundam Clin Pharmacol 1994;8(4):373-8]
itraconazole See also azole antifungals CYP51 : INHIBITS ?
(and metabolism)
(? also inhibits 2C9)
interaction with astemizole, terfenadine, rifampin, oral contraceptives, H2 receptor antagonists, warfarin, cyclosporine, tacrolimus, nifedipine, felodipine, simvastatin, lovastatin, vincristine, [Clin Pharmacokinet 2000 Feb;38(2):111-80]; substantially reduces quinidine clearance, also with triazolam, midazolam, alprazolam

Quick Links:
1A2 2C9 2C19 2D6 2E1 3A4

Page author: jo@anaesthetist.com Last update: 2000-6-22