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Cytochrome P450 : Alphabetical drug list Q |
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| Q | ||
| Drug | CYP interaction | Clinical consequences |
| quinidine | CYP2D6 : INHIBITS (IC50 0.26 µmol) | |
| 3A4 : metabolism
(also 3A5, 3A7) | reduced quinidine clearance by 3A4 inhibitors eg itraconazole, erythromycin, grapefruit juice | |
| 1A2 : mild inhibition | ||
| quinine | 3A4 : (3 hydroxylation) | inhibited by ketoconazole > troleandromycin > doxycycline (Ki 17µM) > omeprazole > primaquine > tetracycline > nifedipine > erythromycin > verapamil > cimetidine > diltiazem > oleandomycin > hydralazine [Br J Clin Pharmacol 1997 Nov;44(5):505-11 ] |
| Quinolones (See individual drugs) | CYP1A2 : INHIBIT | ? interaction with eg aminophyllin |
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| Page author: jo@anaesthetist.com | Last update: 2000-6-22 |