Cytochrome P450 : Alphabetical drug list
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1A2 2C9 2C19 2D6 2E1 3A4
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Drug CYP interaction Clinical consequences
ebrotidine 3A4 : inhibits ? significance [Clin Pharmacol Ther 1999 Apr;65(4):369-76]
econazole 2e1 : inhibits (Ki ~ 4-20 µM) [Xenobiotica 1998 Mar;28(3):293-301] ?
'ecstasy' : see amphetamine
efavirenz (an HIV NNRTI) 3A4 : mild induction potential for interaction with other anti-retrovirals e.g. indinavir, saquinavir
enalapril 3A4 : metabolism ?
encainide 2D6 : metabolism potential for toxicity
enflurane CYP2E1 : METABOLISM ?
enoxacin (see also Quinolones) CYP1A2 : INHIBITS clinically significant [Clin Pharmacol Ther 1999 Mar;65(3):262-74] eg. theophylline
epipodophyllotoxins: see also etoposide, teniposide 3A4 : metabolism see 3A4.
epirubicin ? interaction with cimetidine! [Clin Oncol (R Coll Radiol) 1998;10(1):35-8]
ergotamine, dihydroergotamine 3A4 : METABOLISM ergotism occurs with 3A4 inhibitors even with a single dose of ergotamine tartrate! [ Postgrad Med J 1999 Sep;75(887):546-7], and even 5 days of clarithromycin Rx [Arch Intern Med 1996 Feb 26;156(4):456-8]
3A4 : inhibits May interact with eg zonisamide, tacrolimus, cyclosporine.
estradiol (see also ethinylestradiol) CYP1A2 ?
3A4 : substrate ?
( See
CYP3A4 : metabolism (NOT 3A5 !) ?
3A4 : INHIBITS Clinically relevant : a host of drugs!
ethanol ('alcohol') CYP2C9 : ? induces ?
CYP2E1 : METABOLISM interactions with eg. disulfiram
CYP2E1 ( chronic intake INDUCES, acute INHIBITS ) may increase e.g. paracetamol hepatotoxicity
ethinylestradiol CYP3A4 : metabolism 3A4 induction can reduce effectiveness of oral contraceptives e.g. oxcarbazepine; also perhaps with rifampin or rifabutin, and ritonavir (interaction with HIV protease inhibitors )
NO interaction with lansoprazole [Int J Clin Pharmacol Ther 1997 Jan;35(1):14-8]
3A4 : possible inhibition ?
ethosuximide 3A4 : METABOLISM (no inhibition) interaction potential with other anticonvulsants, probably clinically relevant, and e.g. rifampicin
etomidate ? 2E1 : INHIBITS at concentrations of 0.3mM {? impaired EDHF release }
CYP17 : inhibits ?
CYP11B1 : potently inhibits {more so than ketoconazole } 'adrenal suppression'
etoposide 3A4 : metabolism (and 1A2, 2E1 to a minor degree) [J Pharmacol Exp Ther 1998 Sep;286(3):1294-300] potential for clinical interaction with 3A4 inhibitors

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1A2 2C9 2C19 2D6 2E1 3A4

Page author: jo@anaesthetist.com Last update: 2000-6-22