Cytochrome P450 : Alphabetical drug list
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1A2 2C9 2C19 2D6 2E1 3A4
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Drug CYP interaction Clinical consequences
salmeterol 3A4 : metabolism unlikely to be significant
saquinavir (HIV PI) 3A4 : metabolism ?
3A4 : INHIBITS (less than ritonavir, indinavir) interaction with eg astemizole, cisapride.
secobarbital (See also Barbiturates) 2C9 : INDUCES interaction potential
Selective Serotonin Reuptake Inhibitors (SSRIs) (See [Clin Pharmacokinet 1997 Dec;33(6):454-71] ) { eg. citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline } 2D6 : paroxetine & fluoxetine inhibit potently high levels of eg. perphenazine, haloperidol, thioridazine, risperidone, tricyclics
1A2: fluvoxamine inhibits high levels of eg. clozapine
3A4: fluvoxamine,fluoxetine inhibit raised eg. alprazolam
2C19: fluvoxamine, fluoxetine inhibit raised eg. diazepam levels
selegiline = L-deprenyl = (-)-deprenyl {MAOI} 2D6 : metabolism
? 2E1 {in mice, anyway}
sertindole (antipsychotic) 2D6 : METABOLISM ; ? also 3A4 many potential problems, as for all 2D6!
sertraline {Lowering of thioridazine concentrations poorly explained} CYP2C19 : METABOLISM (high affinity) ?
2C9 : inhibits; and metabolism (low affinity) ?
3A4 : (?) metabolism [Ther Drug Monit 2000 Apr;22(2):143-54] toxicity reported with erythromycin [Pharmacotherapy 1999 Jul;19(7):894-6]
sevoflurane CYP2E1 : metabolism probably not significant (?)
sildenafil 3A4 : substrate
(? also 2C9)
lower doses (25mg) required if 3A4 inhibited [Drugs 1999 Jun;57(6):967-89] eg ritonavir, saquinavir, ketoconazole, erythromycin, cimetidine;
hypotension may occur
simvastatin (See also HMG Co-A reductase inhibitors) 3A4 METABOLISM rhabdomyolysis with 3A4 inhibitors
sirolimus (= rapamycin) 3A4 : metabolism similar to cyclosporine (3A4)
smoking (tobacco) CYP1A2 : INDUCES ?
1A1 :INDUCES (also by nicotine alone) ?
CYP2A6 : METABOLISES nicotine (and cotinine) ? (note that nicotine metabolism in neonates is slow)
[Clin Pharmacokinet 1999 Jun;36(6):425-38]
? (smoking has potential for interaction with "theophylline, caffeine, tacrine, imipramine, haloperidol, pentazocine, propranolol, flecainide and estradiol")
somatostatin analogues inhibit 3A4 and 2D6 ! [Clin Pharmacol Ther 1998 Aug;64(2):150-9] ?
sparteine 2D6 : metabolism ?
'Statins' : see HMG Co-A reductase inhibitors
SSRI antidepressants (see also Antidepressants, and the reference above)
sufentanil CYP3A4 : metabolism ?
sulfamethoxazole 2C9 : substrate ?
sulphaphenazole = sulfaphenazole ?! CYP2C19 : INHIBITS (Ki about 16 µmol) ?
2C9 : INHIBITS ? (0.5 µmol) 'clinically significant'
sulfinpyrazone = sulphinpyrazone {obsolete : does anybody ever use it?} CYP2C9 : INHIBITS ?
Sulphonamides (sulfonamides) CYP2C9 : INHIBIT ?
suprofen {?} 2C9 : metabolism interaction potential

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1A2 2C9 2C19 2D6 2E1 3A4

Page author: jo@anaesthetist.com Last update: 2000-6-22