UP
Cytochrome P450 : Alphabetical drug list
T
NEXT
Quick Links:
1A2 2C9 2C19 2D6 2E1 3A4
 
Have you read our disclaimer?
T
Drug CYP interaction Clinical consequences
tacrine (cholinesterase inhibitor for Alzheimer's) CYP1A2 : metabolism ? (may need to decrease dosage if given with cimetidine)
tacrolimus (=FK 506) CYP3A4 : METABOLISM ? toxicity with inhibition (quinidine, omeprazole, sulindac), and also nifedipine as well as HIV protease inhibitors (incl. saquinavir, nelfinavir) minor effect from theophylline, diclofenac, indomethacin, phenylbutazone, and cimetidine [Res Commun Mol Pathol Pharmacol 1996 Jan;91(1):57-64]
tamoxifen 2C9 : metabolism ?
3A4 : metabolism
(? also minor metabolism by other CYPs, NOT 2D6)
?
taxoids (paclitaxel, docetaxel,'Taxol') CYP3A4 : metabolism, also CYP2C8 [Bull Cancer 1997 Feb;84(2):125-33], [Eur J Drug Metab Pharmacokinet 1998 Jul-Sep;23(3):417-24] ?
temazepam 3A4 : 'minor' metabolism NO significant interaction with 3A4 inhibitors!! [Ther Drug Monit 1996 Apr;18(2):124-7] (e.g. itraconazole, erythromycin)
teniposide 2C19 : metabolism ?
2C9 : ? INHIBITS ?
3A4: metabolism ?
terbinafine CYP2D6 : INHIBITS (potent) interactions with e.g. nortriptyline, desipramine, perphenazine, metoprolol, encainide, propafenone
terfenadine CYP3A4 : METABOLISM 3A4 inhibition gives fatal arrhythmias : block IKr [Drug Saf 1999;21 Suppl 1:11-8]
3A4: inhibits (IC50 23 µM) ?
testosterone CYP3A4 : metabolism ?
theophylline (with ethylenediamine = aminophyllin) CYP3A4 : METABOLISM TOXICITY with eg. "erythromycin, troleandromycin, roxithromycin, enoxacin, ciprofloxacin, pefloxacin, norfloxacin, ofloxacin, fluoroquinolone T-3262, pipemidic acid, cimetidine, etintidine, propranolol, verapamil, diltiazem, nifedipine, furosemide, some oral contraceptives, viloxazine, allopurinol, ticlopidine, idrocilamide, thiabendazole, disulfiram, influenza- and BCG-vaccination, interferon, and caffeine" [Clin Pharmacokinet 1991 Jan;20(1):66-80]
LOW levels with "isoprenaline (isoproterenol), terbutaline, some corticosteroids, phenytoin, phenobarbital, activated charcoal, felodipine moricizine, benzodiazepines and sulfinpyrazone"
CYP1A2 : metabolism possible interaction with 1A2 inhibitors
2E1 : metabolism ?
thiopental ? 2E1 INHIBITS at concentrations of 0.3mM ?
thioridazine (See also Antipsychotics) CYP2D6 : metabolism fluoxetine massively increases levels! [Exp Toxicol Pathol 1999 Jul;51(4-5):309-14]
2D6 : INHIBITS (IC50 2.7 µM) e.g. inhibition of codeine effect , interaction with mianserin
tiagabine 3A4 : metabolism NO significant interaction with oral contraceptives [Clin Pharmacokinet 2000 Apr;38(4):355-65] or (apparently) other CYP-metabolised agents
ticlopidine CYP2C19 : INHIBITS ?
1A2 : INHIBITS ?
timolol (See also beta blockers) 2D6 : metabolism interaction potential
tirilazad CYP3A4 : metabolism ?
tobacco - see smoking
tolbutamide CYP2C9 : metabolism prolonged hypoglycaemia occurs with low 2C9 activity
CYP2E1 : metabolism ?
2C19 : may also participate in metabolism
tolterodine CYP2D6 : metabolism ?
topiramate 2C19 : INHIBITS ?
torsemide {= torasemide} - a diuretic. CYP2C9 : metabolism <--[Biochem Biophys Res Commun 1999 Jan 27;254(3):628-31], [J Pharmacol Exp Ther 1995 Mar;272(3):1076-81]-> ?
tramadol CYP2D6 : activates -a prodrug. ineffective with low 2D6 activity
tranylcypromine inhibits several CYPs: CYP2A6, CYP2C9, CYP2C19, and CYP2E1 ?
trazodone CYP2D6 : metabolism ? (no interaction with haloperidol)
3A4 : METABOLISM [Biol Psychiatry 2000 Apr 1;47(7):655-61] ? interaction with eg ritonavir, ..
triazolam (See also Benzodiazepines) CYP3A4 : metabolism
(also 3A5, 3A7)
excessive sedation with 3A4 inhibitors eg itraconazole, grapefruit juice
Tricyclic antidepressants (see also antidepressants, and individual drugs) CYP1A2 : low activity ?
CYP2C8 : metabolised ?
CYP2C19 : metabolised ?
CYP2D6 : metabolism ?
CYP2D6 : INHIBITS ?
CYP3A4 : metabolism ?
tri-iodothyronine, T3, (thus T4) 3A4 : inhibited
tripellenamine (1st generation antihistamine) 2D6 : inhibits (Ki ~ 4-6 µM) ?
trofosfamide 3A4 : METABOLISM [Cancer Chemother Pharmacol 1999;44(4):327-34] potential for interaction
troglitazone (thiazolidinedione hypoglycaemic) 3A4 : INDUCED [Clin Pharmacokinet 1999 Aug;37(2):91-104] lowers cyclosporin, terfenadine, fenoxfenadine, atorvastatin; oral contraceptives
troleandromycin (triacetyloleandomycin) 3A4 : INHIBITS many potential interactions - see also macrolides
tropisetron (5HT3 antagonist) 2D6 : metabolism potential for interaction with 2D6 inhibitors
trospium chloride (atropinergic for incontinence) 2D6 : inhibits (Ki 20-51 µM) ?


Quick Links:
1A2 2C9 2C19 2D6 2E1 3A4
 



Page author: jo@anaesthetist.com Last update: 2000-6-22