Cytochrome P450 : Alphabetical drug list
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1A2 2C9 2C19 2D6 2E1 3A4
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Drug CYP interaction Clinical consequences
gemfibrozil (see fibrates) 3A4 [Clin Pharmacokinet 1998 Feb;34(2):155-62] Potential for interaction with 3A4 inhibitors..
gestodene 3A4 : INHIBITS (selectively) ?
glibenclamide { = glyburide } CYP3A4 : metabolism and ? inhibition ? interaction with e.g. fibrates, cyclosporine
glipizide 2C9 : METABOLISM low 2C9 activity causes toxicity (as for phenytoin)
Glucocorticoids 3A4 (3A5,3A7) : INDUCED (See individual agents)
glyburide : see glibenclamide
granisetron (granisetron does not appear to inhibit/induce any CYP) CYP3A4 : metabolism ?
1A2 (? metabolism) ?
grapefruit juice! 3A4 : INHIBITS (24hr, significant) interacts with dihydropyridines (Ca channel blockers), terfenadine, saquinavir, cyclosporine, midazolam, triazolam, verapamil, diazepam; possibly lovastatin, cisapride and astemizole [Br J Clin Pharmacol 1998 Aug;46(2):101-10]
marked increase in diazepam bioavailability [Eur J Drug Metab Pharmacokinet 1998 Jan-Mar;23(1):55-9]
1A2: inhibits ?
growth hormone (GH) induces 3A4 ?

Quick Links:
1A2 2C9 2C19 2D6 2E1 3A4

Page author: jo@anaesthetist.com Last update: 2000-6-22