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Cytochrome P450 : Alphabetical drug list L |
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| L | ||
| Drug | CYP interaction | Clinical consequences |
| labetalol | 2D6 : metabolism, ? inhibits | interaction potential eg. with imipramine |
| lansoprazole (Proton pump inhibitor) - low risk of interactions | CYP1A2 (? induces) | NO effect on theophylline metabolism |
| CYP3A4 : metabolism | ? | |
| CYP2C19 : metabolism | ? | |
| 2C19 : INHIBITS (Ki 3 µmol) | ? | |
| 2D6 : inhibits (Ki 45 µmol) | ? | |
| lercanidipine ! | 3A4 : metabolism | ? |
| levetiracetam - probably NOT a CYP inhibitor | - | Nil |
| levomepromazine ? | 2D6 : INHIBITS | of questionable clinical significance [Int J Clin Pharmacol Ther 1995 Dec;33(12):646-52] but increases bromperidol levels, and may inhibit codeine effect |
| lidocaine : See lignocaine | ||
| lignocaine (=lidocaine) | 1A2 : METABOLISM (may be most important at clinical levels!) [Pharmacol Toxicol 1999 Nov;85(5):201-5] | ? | CYP3A4 : metabolism to MEGX (monoethylglycinexylidide) - NOT a good test of 3A4 activity [Br J Clin Pharmacol 1998 Dec;46(6):535-9] | ? erythromycin, itraconazole may increase levels; rifampicin induces metabolism |
| 2D6 : metabolism ! | ? | |
| 1A2 : mild inhibition | ? | |
| loratadine (non-sedating anti-histamine : appears to lack cardiac toxicity) | 3A4 : inhibits (IC50 32 µM) | ? |
| 2C19 : INHIBITS (Ki 0.17 µM) | ? | |
| 2D6 : metabolism | ? | |
| 3A4 : metabolism | ?; appears safe with e.g. erythromycin | |
| lornoxicam | 2C9 : METABOLISM | ? |
| losartan | CYP2C9 : ACTIVATION | ? potential for less effect with 2C9 inhibition (fluconazole, miconazole, sulphamethoxazole) |
| 3A4 : activation [Pharmacotherapy 2000 Feb;20(2):130-9] | 2C9 + 3A4 inhibition may be needed if activation is to be affected! [J Clin Pharmacol 1999 Apr;39(4):418-24] | |
| lovastatin (See also HMG Co-A reductase inhibitors) | CYP3A4 : METABOLISM
(also 3A5, 3A7) | significant interaction eg. diltiazem massively increases levels [Clin Pharmacol Ther 1998 Oct;64(4):369-77] - rhabdomyolysis |
| 2C9 : INHIBITS | ? | |
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| Page author: jo@anaesthetist.com | Last update: 2000-6-22 |