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Cytochrome P450 : Alphabetical drug list
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Drug CYP interaction Clinical consequences
naproxen CYP1A2 : metabolism ?
2C9 : METABOLISM (S-naproxen)
(? also 2C18 )
?
nefazodone (antidepressant, 'new' class) 3A4 : INHIBITS raised triazolam, alprazolam, cyclosporine, carbamazepine, haloperidol [Clin Pharmacokinet 1997 Oct;33(4):260-75], tacrolimus and cisapride levels , etc.
nelfinavir 2C19 : substrate ?
3A4 : metabolism ?
3A4 : INHIBITS (Ki 4.8 µmol) ?
CYP? : induces interaction with phenytoin! [Intern Med 1999 Mar;38(3):302-3]
nevirapine 3A4 and 2B6 : METABOLISM, little or no inhibition of either [Drug Metab Dispos 1999 Dec;27(12):1488-95]. In fact may INDUCE 3A4. Can decrease methadone levels [Pharmacotherapy 1999 Apr;19(4):471-2]
nicardipine (see also calcium channel blockers) 3A4 : metabolism ?
3A4: INHIBITS (IC50 1 µM ?) ?
2D6 : inhibits (IC50 3 µM ?) interferes with propranolol removal [Fundam Clin Pharmacol 1994;8(4):373-8]
2C9 : inhibits (IC50 9 µM ?) ?
nicotine : See smoking
nifedipine 3A4 : substrate
(also 3A5, 3A7)
complex interaction with e.g. grapefruit juice; rifampin lowers bioavailability
1A2 : inhibits competitively ?
nilutamide 2C19 : substrate ?
nimodipine 3A4 : METABOLISM interaction (?) with 3A4 inhibitors eg. grapefruit juice, carbamazepine, phenobarbitone or epanutin (levels plummet), valproate (increased levels).
nisoldipine 3A4 : substrate interaction with inhibitors (grapefruit juice,.. ? cimetidine) and inducers (rifampicin, phenytoin ..)
1A2 : inhibits ?
nitrendipine 3A4 : substrate interactions with eg. grapefruit juice ; also impaired metabolism with febrile illness! [Clin Pharmacokinet 1992 Sep;23(3):238-48]
Neuroleptics CYP2D6 : low activity toxicity
CYP2D6: hi activity ineffective
Non-steroidal anti-inflammatory drugs (NSAIDs) - SEE ALSO INDIVIDUAL AGENTS. CYP2C9 : metabolism avoid with methotrexate, warfarin, alcohol.
norethindrone (=norethisterone) 2C19 : INDUCES ?
3A4 : metabolism potential for interaction with 3A4 inducers eg. troglitazone, rifampin ( > rifabutin)
norfloxacin 3A4 : INHIBITS ?
norfluoxetine (a fluoxtine metabolite) 3A4 : INHIBITS ?
2C19 : INHIBITS (Ki 7µmol) ?
2D6 : INHIBITS ? interaction potential
nortriptyline 2D6 : metabolism ? interaction with e.g. inhibitors
2D6 : ? inhibits ?


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Page author: jo@anaesthetist.com Last update: 2000-6-22